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The Draize test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5 mL or 0.5 g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for a set amount of time before rinsing it out and recording its effects.
"Typically, animal tests for cosmetics include skin and eye irritation tests where chemicals are rubbed onto the shaved skin or dripped into the eyes of rabbits; repeated oral force-feeding studies lasting weeks or months to look for signs of general illness or specific health hazards, such as cancer or birth defects; and even widely condemned ...
One of Wilhelm Kühne's rabbit optograms from 1878. The window the rabbit was facing appears to be discernible in the image. Optography is the process of viewing or retrieving an optogram, an image on the retina of the eye. A belief that the eye "recorded" the last image seen before death was widespread in the late 19th and early 20th centuries ...
A cluster of millimeter-sized, black-and-white spheres, which were eggs, ejected from frogs Ejection of the spermatozoa of male toads Animal used: Mice Rabbit African clawed frog – Xenopus laevis: Mature (male) toads – Rhinella arenarum: Duration of test: A few days after injection of urine Approximately 48 hours after injection
Baseline color and black and white red-free filtered images are taken prior to injection. The black and white images are filtered red-free (a green filter) to increase contrast and often gives a better image of the fundus than the color image. A 6-second bolus injection of 2-5 cc of sodium fluorescein into a vein in the arm or hand
Finding and snapping a photo of the bunnies in each of seven New York City locations (Wall Street, Chinatown, Brooklyn Bridge, Empire State Building, Public Library, Times Square and Grand Central ...
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In the UK in 2015, there were 3.33 million procedures on rodents (80% of total procedures that year). The most common species used were mice (3.03 million procedures, or 73% of total) and rats (268,522, or 6.5%).