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Pramipexole, sold under the brand Mirapex among others, is a medication used to treat Parkinson's disease ... Common side effects of Pramipexole may include: [17] [4] [5]
Due to the major adverse effects of ergot-derived dopamine agonists, they are generally not used in modern medicine and have mostly been abandoned in favor of non-ergot agonists such as pramipexole, ropinirole and rotigotine. They do not induce as serious side effects although common side effects are nausea, edema and hypotension.
In contrast, pramipexole the (S)-enantiomer is a dopamine agonist and is an approved drug (Mirapex) used in Parkinson's disease. Dexpramipexole is a low molecular weight, orally bioavailable, water-soluble small molecule with linear pharmacokinetics and linear dose proportionality.
Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime.Unusual side effects specific to D 3 agonists such as ropinirole and pramipexole can include hypersexuality, punding and compulsive gambling, even in patients without a history of these behaviours.
Modafinil (Provigil) and pramipexole (Mirapex) have been suggested for treating cognitive dysfunction associated with bipolar depression, but evidence supporting their use is quite limited. [ 25 ] [ 26 ] In addition, riluzole , a glutamatergic drug used in ALS has been studied as an adjunct or monotherapy treatment in bipolar depression, with ...
This is a very unusual side effect. Mainly all substances that mimic the effect of dopamine has adverse effects such as severe hypotension and sudden "sleep attacks". However, these side effects can be reversed. Medications that maybe allowed overcoming excessive daytime sleepiness are the class of selective Norepinephrine reuptake inhibitors ...
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [ 1 ] [ 7 ] Symptoms include high fever , confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [ 1 ]
As with other dopamine agonists (like pramipexole and ropinirole), compulsive behavior like pathological gambling, overeating, excessive shopping, increased libido, sexual and/or other intense urges, may develop. [8] [9] Another rare side effect of piribedil is excessive daytime sleepiness and unintended sleep episodes. [9] [10]