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All medications within the NyQuil imprint contain sedating antihistamines, hypnotics, and/or alcohol; they are intended to be taken before sleep. Its daytime counterpart is antihistamine-free DayQuil, formulated to avoid drowsiness. NyQuil is also used as a sleep aid. [1] NyQuil was first marketed in the United States in 1966. [2] [3]
Diphenhydramine and promethazine are both marketed by names other than Sominex for several indications including and besides their use as sleep aids. For example, diphenhydramine is sold under the brand name Benadryl as an antihistamine for use against allergies. [ 11 ]
The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen (paracetamol) in Tylenol PM and ibuprofen in Advil PM. Diphenhydramine can cause minor psychological dependence. [28] Diphenhydramine has also been used as an anxiolytic. [29]
The shorter elimination half-life of diphenhydramine (4–8 hours) compared to doxylamine may give it an advantage over doxylamine as a sleep aid in this regard. [27] Antihistamines like doxylamine are sedating initially but tolerance occurs with repeated use and can result in rebound insomnia upon discontinuation. [7] [28]
In sleep medicine, we use very small doses of melatonin multiple hours before bed to help gradually shift the body’s clock (circadian rhythm) in people with delayed sleep phase disorder, jet lag ...
[35] [1] Its molecular formula is C 23 H 23 N 6 O 2 Cl and its molecular weight is 450.93 g/mol (or 487.38 g/mol for the hydrochloride). [35] [1] Daridorexant hydrochloride is a white to light yellowish powder. [1] Daridorexant is a lipophilic compound and daridorexant hydrochloride is very slightly soluble in water. [7] [1]
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