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A metamyelocyte is a cell undergoing granulopoiesis, derived from a myelocyte, and leading to a band cell. It is characterized by the appearance of a bent nucleus , cytoplasmic granules, and the absence of visible nucleoli .
When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even though myelocytes are smaller cells.
Other features may include; leukocytosis (50% of cases); left shift and dysplasia of monocytes and granulocytes; presence of metamyelocytes, myelocytes and promonocytes; monocytes with hypersegmented/abnormal shaped nuclei, increased cytoplasmic basophilia and/or the presence of cytoplasmic granules; eosinophilia (in cases of CMML with ...
A band cell (also called band neutrophil, band form or stab cell) is a cell undergoing granulopoiesis, derived from a metamyelocyte, and leading to a mature granulocyte. It is characterized by having a curved but not lobular nucleus. [1] The term "band cell" implies a granulocytic lineage (e.g., neutrophils). [2]
A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.
Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow.
Bone marrow aspirate showing normal "trilineage hematopoiesis": myelomonocytic cells (an eosinophil myelocyte marked), erythroid cells (an orthochromatic erythroblast marked), and megakaryocytic cells Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate
Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Comprehensive diagram that shows the development of different blood cells from haematopoietic stem cell to mature cells in both myeloid and lymphoid lineages.