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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Levels further down the Racine stages also contain symptoms of the previous stages. For example, an animal that is demonstrating the actions of a stage four seizure may also demonstrate head nodding (indicative of a level two seizure). [3] It is known that repeated exposure to a stimuli lowers the overall threshold for a seizure.
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone.
Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid used medically to treat chronic pain and opioid use disorder. [7] Prescribed for daily use, the medicine relieves cravings and opioid withdrawal symptoms. [10]
It is used for operative and accident-related pain in small mammals such as dogs, cats, ferrets, coatis, raccoons, mongooses, various marsupials, some rodents and perhaps some larger birds. Although butorphanol is commonly used for pain relief in reptiles, no studies (as of 2014) have conclusively shown that it is an effective analgesic in ...
Opiate overdose symptoms and signs can be referred to as the "opioid toxidrome triad": decreased level of consciousness, pinpoint pupils and respiratory depression. Other symptoms include seizures and muscle spasms. Sometimes an opiate overdose can lead to such a decreased level of consciousness such that the person will not wake up.
A bottle of veterinary pharmaceutical potassium bromide oral solution used in dogs, primarily as an antiepileptic (to stop seizures) [3] In dogs, epilepsy is often an inherited condition. The incidence of epilepsy/seizures in the general dog population is estimated to be between 0.5% and 5.7%. [4]
Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control. Any reduction in the frequency of seizures is compared against a placebo. [21]
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