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Treatments with anticancer chemotherapeutic agents often are toxic to the cells of the brain, leading to memory loss and cognitive dysfunction that can persist long after the period of exposure. This condition, termed chemo brain, appears to be due to DNA damages that cause epigenetic changes in the brain that accelerate the brain aging process ...
Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10 and 15 per thousand person-years for all dementias and 5–8 for AD, [236] [237] which means that half of new dementia cases each year are Alzheimer's disease. Advancing age is a primary risk factor for ...
Familial Alzheimer's disease mutations commonly used in animal models. Rodent animal models of Alzheimer's disease are commonly used in research as rodents and humans have many of the same major brain regions and neurotransmitter systems. [5] These models are small, easy to house, as well as breed very well. [26]
In Alzheimer’s disease, the most common form of dementia, the blood-brain barrier is disrupted. A new study has uncovered unique molecular signatures linked to the disruption of this blood-brain ...
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14]
The brain is very complex, and is composed of many different areas and types of tissue, or matter. The different functions of different tissues in the brain may be more or less susceptible to age-induced changes. [6] The brain matter can be broadly classified as either grey matter, or white matter.
Lifestyle changes. According to the Mayo Clinic some key lifestyle changes to support brain health include the following: Avoid smoking. Control vascular risk factors, including high blood ...
People who die of severe COVID-19 have brain abnormalities that resemble changes seen in Alzheimer's disease - accumulation of a protein called tau inside brain cells, and abnormal amounts of the ...