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In CDK-cyclin complexes, this activation region is composed of a conserved αL-12 Helix and contains a key phosphorylatable residue (usually Threonine for CDK-cyclin partners, but also includes Serine and Tyrosine) that mediates the enzymatic activity of the CDK. It is at this essential residue (T160 in CDK2 complexes, T177 in CDK6 complexes ...
A Primary Key is a set of attributes that uniquely identifies items in a DynamoDB Table. Creation of a DynamoDB Table requires definition of a Primary Key. Each item in a DynamoDB Table is required to have all of the attributes that constitute the Primary Key, and no two items in a Table can have the same Primary Key.
Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. [ 5 ] [ 6 ] CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with ...
CDK-activating kinase (CAK) activates the cyclin-CDK complex by phosphorylating threonine residue 160 in the CDK activation loop. CAK itself is a member of the Cdk family and functions as a positive regulator of Cdk1 , Cdk2 , Cdk4 , and Cdk6 .
Dynamo is a set of techniques that together can form a highly available key-value structured storage system [1] or a distributed data store. [1] It has properties of both databases and distributed hash tables (DHTs).
A second cyber incident at data provider CDK Global, whose software is used at 15,000 auto dealers, continued to slow operations to a near-standstill Thursday at US and Canada dealerships, the ...
State-transition tables are sometimes one-dimensional tables, also called characteristic tables. They are much more like truth tables than their two-dimensional form. The single dimension indicates inputs, current states, next states and (optionally) outputs associated with the state transitions.
Example of a star schema; the central table is the fact table. In data warehousing, a fact table consists of the measurements, metrics or facts of a business process. It is located at the center of a star schema or a snowflake schema surrounded by dimension tables. Where multiple fact tables are used, these are arranged as a fact constellation ...