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In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
Peak and trough levels are usually monitored, and for research purposes the area under the concentration curve is also sometimes used. [29] Toxicity is best monitored by looking at trough values. [29] Immunoassays are commonly used to measure vancomycin levels. [27]
Direct measurement 60.9 mmol/L ... Peak–trough fluctuation within one dosing interval at steady state. ... Vancomycin; Bronchodilator. medication Cytostatic.
It is a standard measurement in pharmacokinetics. Description. C max is the opposite of C min, which is the minimum (or trough) ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
This definition is slightly different from C trough, the concentration immediately prior to administration of the next dose. [1] C min is the opposite of C max, the maximum concentration that the drug reaches. C min must be above certain thresholds, such as the minimum inhibitory concentration (MIC), to achieve a therapeutic effect. [2]