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Quetiapine has an elimination half-life of 6 or 7 hours. [86] [7] [8] Its metabolite, norquetiapine, has a half-life of 9 to 12 hours. [7] [8] Quetiapine is excreted primarily via the kidneys (73%) and in feces (20%) after hepatic metabolism, the remainder (1%) is excreted as the drug in its unmetabolized form. [82] [86] Skeletal formula of ...
Clotiapine (Entumine) is an atypical antipsychotic [2] of the dibenzothiazepine chemical class. [3] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.
The antipsychotic quetiapine is typically dosed two to three times daily for the management of schizophrenia. [3] A simpler regimen would be a once daily administered antipsychotic. [1] For example, risperidone can be administered once daily. [4] A lack of adherence can lead to poor health outcomes, as well as unnecessary financial burden. [5]
[4] [5] Antipsychotics like quetiapine and olanzapine and antidepressants like trazodone and mirtazapine are all potent serotonin 5-HT 2A receptor antagonists. [6] [28] [29] Conversely, benzodiazepines and alcohol act as positive allosteric modulators of the GABA A receptor and have anxiolytic and sedative effects. [30]
Fesoterodine (INN, used as the fumarate under the brand name Toviaz) is an antimuscarinic drug developed by Schwarz Pharma AG to treat overactive bladder syndrome (OAB). [2] It was approved by the European Medicines Agency in April 2007, [3] the US Food and Drug Administration on October 31, 2008 [4] and Health Canada on February 9, 2012.
Lithium and quetiapine are not statistically different in terms of hypothyroidism rates. However, lithium users are tested much more frequently for hypothyroidism than those using other drugs. The authors write that there may be an element of surveillance bias in understanding lithium's effects on the thyroid glands, as lithium users are tested ...
This is a list of radioactive nuclides (sometimes also called isotopes), ordered by half-life from shortest to longest, in seconds, minutes, hours, days and years. Current methods make it difficult to measure half-lives between approximately 10 −19 and 10 −10 seconds.
Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia.It has been used in Germany since 1990 (although it has been discontinued in Germany) and Japan since 1982.