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Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. [1] Lower urinary tract infections may involve the bladder ( cystitis ) or urethra ( urethritis ) while upper urinary tract infections affect the kidney ( pyelonephritis ). [ 10 ]
Tetrahydrofolate synthesis pathway The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [ 25 ] [ 26 ] [ 27 ] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway.
The clinical pathway concept appeared for the first time at the New England Medical Center (Boston, United States) in 1985, inspired by Karen Zander and Kathleen Bower. [9] [non-primary source needed] Clinical pathways appeared as a result of the adaptation of the documents used in industrial quality management, the standard operating procedures (SOPs), whose goals are:
Nitrofurantoin was first sold in 1953. [17] It is on the World Health Organization's List of Essential Medicines. [18] It is available as a generic medication. [16] In 2022, it was the 158th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [19] [20]
Vibegron was first discovered by scientists at Merck & Co. Inc. [7] and was later developed in Japan by Kyorin Pharmaceutical Co., Ltd, Kissei Pharmaceutical Co., Ltd, and Urovant Sciences. [8] It was approved for medical use in Japan in September 2018, [ 8 ] in the United States in December 2020, [ 1 ] [ 5 ] [ 6 ] and in the European Union in ...
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Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
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