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  2. Fixed allele - Wikipedia

    en.wikipedia.org/wiki/Fixed_allele

    These random fluctuations within the allele frequencies can lead to the fixation or loss of certain alleles within a population. To the right is an image that shows through successive generations; the allele frequencies fluctuate randomly within a population. The smaller the population size, the faster fixation or loss of alleles will occur.

  3. Loss of heterozygosity - Wikipedia

    en.wikipedia.org/wiki/Loss_of_heterozygosity

    The remaining copy of the tumor suppressor gene can be inactivated by a point mutation or via other mechanisms, resulting in a loss of heterozygosity event, and leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell).

  4. Gene conversion - Wikipedia

    en.wikipedia.org/wiki/Gene_conversion

    Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic, meaning that one allele of the same gene replaces another allele, or ectopic, meaning that one paralogous DNA sequence converts another.

  5. Genetic drift - Wikipedia

    en.wikipedia.org/wiki/Genetic_drift

    In these simulations, alleles drift to loss or fixation (frequency of 0.0 or 1.0) only in the smallest population. Assuming genetic drift is the only evolutionary force acting on an allele, after t generations in many replicated populations, starting with allele frequencies of p and q , the variance in allele frequency across those populations is

  6. Negative selection (natural selection) - Wikipedia

    en.wikipedia.org/wiki/Negative_selection...

    [2] [3] Purging of deleterious alleles can be achieved on the population genetics level, with as little as a single point mutation being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool.

  7. Microevolution - Wikipedia

    en.wikipedia.org/wiki/Microevolution

    That is, the alleles in the offspring in the population are a random sample of those in the parents. And chance has a role in determining whether a given individual survives and reproduces. A population's allele frequency is the fraction or percentage of its gene copies compared to the total number of gene alleles that share a particular form. [28]

  8. Selective sweep - Wikipedia

    en.wikipedia.org/wiki/Selective_sweep

    [2] Finally, a "multiple origin soft sweep" occurs when mutations are common (for example in a large population) so that the same or similar beneficial mutations occurs on different genomic backgrounds such that no single genomic background can hitchhike to high frequency. [3] This is a diagram of a hard selective sweep.

  9. Genetic recombination - Wikipedia

    en.wikipedia.org/wiki/Genetic_recombination

    Most recombination occurs naturally and can be classified into two types: (1) interchromosomal recombination, occurring through independent assortment of alleles whose loci are on different but homologous chromosomes (random orientation of pairs of homologous chromosomes in meiosis I); & (2) intrachromosomal recombination, occurring through ...

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