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MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2 , and functions as a pattern recognition receptor capable of detecting viruses .
RIG-I domain architecture. (A) Schematic representation of full-length RIG-I. (B) X-ray crystal structure of RNA-bound RIG-I ( ), excluding the CARD domains.The RLR receptors are members of the DEAD-box (SF2) helicase family (despite containing a DExD/H motif, rather than the DEAD motif characteristic of the family) and share a common domain architecture.
At a resting state for the cell, a protein called mitofusin 2 (MFN2) is known to interact with MAVS, preventing MAVS from binding to the cytosolic proteins, such as RIG-I and MDA5. [ 7 ] [ 8 ] Upon recognition of the virus in the cytosol, mitochondria-associated ER membranes (MAM) and mitochondria will become physically tethered by MFN2 and RIG ...
Médiaszolgáltatás-támogató és Vagyonkezelő Alap (MTVA) (English: Media Services and Support Trust Fund) is a Hungarian fund company owned and financed by the Hungarian state, through the National Media and Infocommunications Authority (Hungarian: Nemzeti Média- és Hírközlési Hatóság, NMHH).
The MD5 message-digest algorithm is a widely used hash function producing a 128-bit hash value. MD5 was designed by Ronald Rivest in 1991 to replace an earlier hash function MD4, [3] and was specified in 1992 as RFC 1321.
MDA (company), a Canadian space technology company Magen David Adom, Israel's emergency medical, disaster, ambulance and blood bank service; Malaysia Design Archive, a non-profit private organization
Magyar Építéstechnika (magazine of ÉVOSZ) Magyar Sakkvilág (chess magazine) Marie Claire (women's magazine) Men's Health (men's magazine) National Geographic (scientific journal) PC Guru (computer games) PC World (computer magazine) Playboy (men's magazine) Rádiótechnika (radio-electronic journal) Zsaru (criminal magazine)
On July 1, 2015, Magyar Rádió and the three other public media organisations managed by the MTVA were merged into a single organisation called Duna Media Service (Hungarian: Duna Médiaszolgáltató). [3] This organization is the legal successor to Magyar Rádió and is an active member of the European Broadcasting Union. [4] [5]