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para-Methoxyphenylpiperazine (pMeOPP), also known as 4-methoxyphenylpiperazine (4-MeOPP), is a substituted piperazine derivative with stimulant effects which has been sold as an ingredient in "Party pills", initially in New Zealand and subsequently in other countries around the world. [1]
Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C 4 H 10 N 2 ·2C 6 H 8 O 7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C 4 H 10 N 2 ·C 6 H 10 O 4 (containing 1 molecule each of piperazine and adipic acid). [6]
[1] [2] [4] This is in contrast to the related drug meta-chlorophenylpiperazine (mCPP), which shows high affinity for both the serotonin 5-HT 1A and 5-HT 2 receptors. [ 5 ] [ 2 ] oMeOPP and mCPP have both been found to suppress conditioned avoidance responses (CARs) without markedly affecting escape behavior in animals, indicative that they ...
Substituted piperazines are a class of chemical compounds based on a piperazine core. [1] Some are used as recreational drugs and some are used in scientific research . [ 2 ]
The odors tend to be undesirable, as in the case of certain wines, [1] or as defensive chemicals used by insects such as Harmonia axyridis which produces isopropyl methoxy pyrazine (IPMP). They have also been identified as additives in cigarette manufacture. Detection thresholds are very low, typically near 2 parts per trillion (1 ng/L). [1]
1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring. [1] The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class. [2] It is a rigid analogue of amphetamine.
WAY-100635 is a piperazine drug and research chemical widely used in scientific studies. It was originally believed to act as a selective 5-HT 1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D 4 receptor. [1] [2] [3] It is sometimes referred to as a silent antagonist at the former receptor. [4]
ortho-Methylphenylpiperazine (also known as oMPP, oMePP, 1-(2-methylphenyl)piperazine, 2-MPP, and 2-MePP) is a psychoactive designer drug of the phenylpiperazine group. [1] [2] It acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC 50 values for induction of monoamine release of 175 nM for serotonin, 39.1 nM for norepinephrine, and 296–542 nM for dopamine.
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