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Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea , cutaneous candidiasis , pityriasis versicolor , dandruff , and seborrheic dermatitis . [ 12 ]
Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor. [1] [2] It is applied to the affected area as a lotion or shampoo. [3]
Tinea versicolor (also pityriasis versicolor) is a condition characterized by a skin eruption on the trunk and proximal extremities. [1] The majority of tinea versicolor is caused by the fungus Malassezia globosa, although Malassezia furfur is responsible for a small number of cases.
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Regular use of an over-the-counter or prescription antifungal shampoo or cream is a common treatment. The topical antifungal medications ketoconazole and ciclopirox have the best evidence. [10] Ketoconazole should be used twice per week. [8] Shampoo or soap containing zinc pyrithione or selenium disulfide is also used. [8]
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It is not due to poor hygiene, [6] [7] and the underlying mechanism involves the excessive growth of skin cells. [5] Diagnosis is based on symptoms. [3] There is no known cure for dandruff. [8] Antifungal cream, such as ketoconazole, or the keratolytic agent salicylic acid may be used to try to improve the condition.
Superficial scrapes of skin examined underneath a microscope may reveal the presence of a fungus.This is done by utilizing a diagnostic method called KOH test, [6] wherein the skin scrapings are placed on a slide and immersed on a dropful of potassium hydroxide solution to dissolve the keratin on the skin scrappings thus leaving fungal elements such as hyphae, septate or yeast cells viewable.