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Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
Extended patch testing may be useful to also rule out allergic contact causes. [5] If the skin biopsy show signs of other components such as bacteria, the healthcare workers can do further lab testing such as culture or other test like a diascopy. [25] Other skin diseases that may resemble perioral dermatitis include: Rosacea; Acne vulgaris
If there is a persistent sore that does not heal or a growing lump within the rash, a skin biopsy should be performed to rule out the possibility of skin cancer. If the erythema ab igne lesions demonstrate pre-cancerous changes, the use of 5-fluorouracil cream has been recommended.
Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [4] [5] Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ().
Oral retinoids (e.g., acitretin, [4] [12] [13] etretinate [14]) may be helpful in treating arsenic-induced cutaneous lesions and in reducing the risk of cutaneous and internal malignancy formation, especially in Bowman's disease. Topical 5-fluorouracil cream [13] or 5% imiquimod cream [15] may be useful in treating arsenical keratoses and Bowen ...
Skin Biology and Diseases. The programs comprising Skin Biology and Diseases support a broad portfolio of basic, translational, and clinical research in skin. These efforts include work on the developmental and molecular biology of skin and skin appendages (such as the hair follicle), the study of skin as an immune organ, and the genetics of ...
A rheumatologist (a physician specializing in autoimmune diseases) may use physical examinations, health history, blood tests and x-rays to accurately diagnose psoriatic arthritis. Factors that contribute to a diagnosis of psoriatic arthritis include the following: Psoriasis in the patient, or a family history of psoriasis or psoriatic arthritis.