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The adrenal glands are surrounded by a fatty capsule and lie within the renal fascia, which also surrounds the kidneys. A weak septum (wall) of connective tissue separates the glands from the kidneys. [11] The adrenal glands are directly below the diaphragm, and are attached to the crura of the diaphragm by the renal fascia. [11]
Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. [1] The genetic disorder McCune–Albright syndrome can also present as Cushing's syndrome in affected patients. Adrenal gland (zona fasciculata layer).
Sagittal section through posterior abdominal wall, showing the relations of the capsule of the kidney (pararenal fat labeled as paranephric body center left) Perirenal space. It is also called the perinephric space. Bounded by the anterior and posterior leaves of the renal fascia. It contains the following structures: Adrenal gland; Kidney ...
The adrenal cortex is the outer region and also the largest part of the adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. It is also a secondary site of androgen synthesis. [2]
Waterhouse–Friderichsen syndrome (WFS) is defined as adrenal gland failure due to bleeding into the adrenal glands, commonly caused by severe bacterial infection. Typically, it is caused by Neisseria meningitidis. [1] The bacterial infection leads to massive bleeding into one or (usually) both adrenal glands. [2]
The renal fascia is a dense, elastic connective tissue envelope enclosing the kidney and adrenal gland, together with the layer of perirenal fat surrounding these two. [1]The renal fascia separates the adipose capsule of kidney from the overlying pararenal fat.
The right kidney sits just below the diaphragm and posterior to the liver. The left kidney sits below the diaphragm and posterior to the spleen. On top of each kidney is an adrenal gland. The upper parts of the kidneys are partially protected by the 11th and 12th ribs.
The zona glomerulosa (sometimes, glomerular zone) of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule. Its cells are ovoid and arranged in clusters or arches (glomus is Latin for "ball"). [citation needed] H & E staining of the adrenal cortex.