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As of 2016 the evidence on the efficacy of radiation therapy was considered inadequate in quantity and quality, and difficult to interpret because of uncertainty about the natural history of Dupuytren's disease. [32] Needle aponeurotomy is most effective for Stages I and II, covering 6–90 degrees of deformation of the finger.
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen.It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous ...
The causes of some deformities, such as Dupuytren's contracture, are difficult to determine exactly, however chances of developing the deformity may be increased by certain chronic behaviours or disease. [3] Consequences can be similar to trauma related ones, in that joint use may be disrupted. [20]
The systematic review states "On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects." this is based on "Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study.
Microneedles (MNs) are medical tools used for microneedling, primarily in drug delivery, disease diagnosis, and collagen induction therapy. Known for their minimally invasive and precise nature, MNs consist of arrays of micro-sized needles ranging from 25μm to 2000μm.
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Hypodermic needles are normally made from a stainless-steel or Niobium tube [17] through a process known as tube drawing where the tube is drawn through progressively smaller dies to make the needle. The end of the needle is bevelled to create a sharp pointed tip, letting the needle easily penetrate the skin. [18] A hypodermic needle tip under ...
Garrod's pads are named after Archibald Garrod who first documented them in 1904 in association with Dupuytren's contracture. [3] H.A. Bird described them as an incidental finding in a professional violinist and proposed that they arise in such cases due to repeated extreme tension of the extensor tendons over the interphalangeal joints. [4]
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