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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
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The yotari mouse is an autosomal recessive mutant. [1] It has a mutated disabled homolog 1 ( Dab1 ) gene. [ 2 ] This mutant mouse is recognized by unstable gait ("Yota-ru" in Japanese means "unstable gait") and tremor and by early deaths around the time of weaning .
President-elect Donald Trump has long supported House Speaker Mike Johnson — hosting him on election night, bringing him to the Army-Navy college football game last weekend and backing him ...
Following the Lions’ dramatic 34-31 last-second win over the Packers, head coach Dan Campbell stated his philosophy for his gutsy fourth-and-1 call: “Let’s finish this.” Detroit converted ...
A webcam is a video camera which is designed to record or stream to a computer or computer network. They are primarily used in video telephony, live streaming and social media, and security. Webcams can be built-in computer hardware or peripheral devices, and are commonly connected to a device using USB or wireless protocol.