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New or worsening kidney problems, including kidney failure; Onset of depressive disorders or mood changes; Changes in bone such as osteonecrosis (breakdown and death of bone) Increases or redistribution of body fat; Immune system changes (e.g. Immune Reconstitution Syndrome)
Tenofovir disoproxil is used for HIV-1 infection and chronic hepatitis B treatment. For HIV-1 infection, tenofovir is indicated in combination with other antiretroviral agents for people 2 years of age and older. For chronic hepatitis B patients, tenofovir is indicated for patients 12 years of age and older. [10]
Tenofovir, also known as TDF is a so-called 'prodrug' with the active compound deactivated by a molecular side chain that dissolves in the human body allowing a low dose of tenofovir to reach the site of desired activity. One example of the prodrug form is tenofovir disoproxil fumarate with the trade name Viread (Gilead Sciences Inc USA).
It is used for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease [8] and is given in combination with other medications for the prevention and treatment of HIV. It is taken by mouth. [6] Tenofovir alafenamide is a nucleotide reverse transcriptase inhibitor and is a prodrug of tenofovir.
tenofovir/emtricitabine, elvitegravir (an integrase inhibitor) and cobicistat (inhibiting metabolism of the former) in patients with good kidney function (gfr > 70) tenofovir/emtricitabine, ritonavir, and darunavir (both latter are protease inhibitors) Both efavirenz and nevirapine showed similar benefits when combined with NRTI respectively. [55]
Underlying hepatitis B virus (HBV) can interact with emtricitabine to cause significant liver damage, but it does not have a significant detrimental effect on the liver when given to patients without HBV. [18] Tenofovir alafenamide (TAF) is a prodrug of tenofovir that functions as a nucleotide reverse transcriptase inhibitor (NtRTI). Other ...
Patients are advised to discuss any history of bone issues, kidney issues, or hepatitis B infection with their healthcare provider. [19] Effectiveness of PrEP for prevention of infection is reliant on an individual's ability to take the medication consistently. [20] Emtricitabine/tenofovir is also used for HIV post-exposure prophylaxis. People ...
Recommended dosage for efavirenz/emtricitabine/tenofovir is one tablet at or before bedtime. Side effects can be reduced if it is taken on an empty stomach. People with kidney or liver problems can take one tablet by mouth once a day. However, people whose CrCl levels are less than 50ml/min should not follow this dosage.
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