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The paramedian pontine reticular formation (PPRF) is a subset of neurons of the oral and caudal pontine reticular nuclei. With the abducens nucleus it makes up the horizontal gaze centre . [ 1 ] It is situated in the pons adjacent to the abducens nucleus . [ 2 ]
Structures affected by the lesion are the dorsal pons (pontine tegmentum) which comprises paramedian pontine reticular formation (PPRF), nuclei of cranial nerves VI and VII, corticospinal tract, medial lemniscus, and the medial longitudinal fasciculus. There is involvement of the fifth to eighth cranial nerves, central sympathetic fibres ...
Medial inferior pontine syndrome is a condition associated with a contralateral hemiplegia. [ citation needed ] "Medial inferior pontine syndrome" has been described as equivalent to Foville's syndrome .
Scheme showing anatomical location of lesions in one and a half syndrome. The syndrome usually results from single unilateral lesion of the paramedian pontine reticular formation and the ipsilateral medial longitudinal fasciculus.
Benedikt syndrome, also called Benedikt's syndrome or paramedian midbrain syndrome, is a rare type of posterior circulation stroke of the brain, with a range of neurological symptoms affecting the midbrain, cerebellum and other related structures. Ipsilateral third nerve palsy presenting with ptosis,abduction of eye. Contralateral flapping tremor.
The pontine tegmentum, or dorsal pons, is the dorsal part of the pons located within the brainstem. The ventral part or ventral pons is known as the basilar part of the pons , or basilar pons. Along with the dorsal surface of the medulla oblongata , it forms part of the rhomboid fossa – the floor of the fourth ventricle .
The paramedian pontine reticular formation (PMPRF) is involved in coordinating horizontal conjugate eye movements and saccades. To do so, besides projecting to the ibsilateral abducens nucleus, the PMPRF projects fibers through the MLF to the contralateral oculomotor nucleus (specifically, those of its motor neurons that innervate the medial rectus muscle).
The infarction (which arises in the paramedian branches of the anterior spinal artery and/or the vertebral arteries) leads to death of the ipsilateral medullary pyramid, the medial lemniscus, and the hypoglossal nerve fibers that pass through the medulla.