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The S9 fraction is most frequently used in assays that measure the metabolism of drugs and other xenobiotics. It is defined by the U.S. National Library of Medicine 's " IUPAC Glossary of Terms Used in Toxicology" [ 1 ] as the " Supernatant fraction obtained from an organ (usually liver) homogenate by centrifuging at 9000 g for 20 minutes in a ...
In the liver, bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase, first to bilirubin glucuronide and then to bilirubin diglucuronide, making it soluble in water: the conjugated version is the main form of bilirubin present in the "direct" bilirubin fraction. Much of it goes into the bile and thus out into the small ...
The "Hepatic Extraction Ratio" is a similar measurement for clearance of a substance (usually a pharmacological drug) by the liver. It is defined as the fraction of drug removed from blood by the liver, and depends on 3 factors— the hepatic blood flow, the uptake into the hepatocytes, and the enzyme metabolic capacity.
The protein serum consists of the serum protein which is about 6 to 8 g/dl then albumin makes 3.5 to 5.0 g/dl then the rest should be the globulins. The section where globulins fractions are located is made up of proteins, enzymes, and immunoglobulins. Usually, these compounds are arranged in the liver.
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
Risk Factors for Fatty Liver Disease. Having overweight or obesity is a major risk factor for fatty liver disease. Estimates suggest that up to 75 percent of people with overweight have NAFLD, and ...
A prime number is a number greater than 1 that can only be divided by… Answer: One and itself. What is the sum of the interior angles of a triangle? Answer: 180 degrees. What is the square root ...
The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis, carrier proteins, hormones, prohormones and apolipoprotein: