Search results
Results from the WOW.Com Content Network
Bacteria are marked as sensitive, resistant, or having intermediate resistance to an antibiotic based on the minimum inhibitory concentration (MIC), which is the lowest concentration of the antibiotic that stops the growth of bacteria. The MIC is compared to standard threshold values (called "breakpoints") for a given bacterium and antibiotic. [28]
Nowadays, the MIC is used in antimicrobial susceptibility testing. The MIC is reported by providing the susceptibility interpretation next to each antibiotic. The different susceptibility interpretations are: "S" (susceptible or responding to a standard dosing regimen), "I" (intermediate or requiring increased exposure), and "R" (resistant).
In applied statistics, the Morris method for global sensitivity analysis is a so-called one-factor-at-a-time method, meaning that in each run only one input parameter is given a new value. It facilitates a global sensitivity analysis by making a number r {\displaystyle r} of local changes at different points x ( 1 → r ) {\displaystyle x(1 ...
Two types of clamp are quite commonly used. The hyperglycemic clamp, which requires maintaining a high blood sugar level by perfusion or infusion with glucose, is a way to quantify how fast beta-cells respond to glucose. The hyperinsulinemic clamp, which requires maintaining a high insulin level by perfusion or infusion with insulin, is a way ...
Sensitivity and specificity values alone may be highly misleading. The 'worst-case' sensitivity or specificity must be calculated in order to avoid reliance on experiments with few results. For example, a particular test may easily show 100% sensitivity if tested against the gold standard four times, but a single additional test against the ...
EE is applied to identify non-influential inputs for a computationally costly mathematical model or for a model with a large number of inputs, where the costs of estimating other sensitivity analysis measures such as the variance-based measures is not affordable. Like all screening, the EE method provides qualitative sensitivity analysis ...
The authors have tested HOMA and HOMA2 extensively against other measures of insulin resistance (or its reciprocal, insulin sensitivity) and β-cell function. [4] [8] [9] The approximation formulae above relate to HOMA and are crude estimates of the model near normal levels of glucose and insulin in man.
A drug will not have a single value of EC 50 due to different tissues having different sensitivities to the drug (in part due to tissue specific receptor expression). [ citation needed ] Furthermore, EC 50 is dependent on many factors including species, tissue and cell type and genetics.