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A foreign body reaction (FBR) is a typical tissue response to a foreign body within biological tissue. [1] It usually includes the formation of a foreign body granuloma . [ 2 ] Tissue encapsulation of an implant is an example, as is inflammation around a splinter . [ 3 ]
[9] [24] In order for a biodegradable polymer to be used as a therapeutic, it must meet several criteria: 1) be non-toxic in order to eliminate foreign body response; 2) the time it takes for the polymer to degrade is proportional to the time required for therapy; 3) the products resulting from biodegredation are not cytotoxic and are readily ...
Protein adsorption influences the interactions that occur at the tissue-implant interface. Protein adsorption can lead to blood clots, the foreign-body response and ultimately the degradation of the device. In order to counter-act the effects of protein adsorption, implants are often coated with a polymer coating to decrease protein adsorption.
Chitosan has many excellent characteristics for biomedical science. Chitosan is biocompatible, it is highly bioactive, meaning it stimulates a beneficial response from the body, it can biodegrade which can eliminate a second surgery in implant applications, can form gels and films, and is selectively permeable. These properties allow for ...
Host response is defined as the "response of the host organism (local and systemic) to the implanted material or device". Most materials will have a reaction when in contact with the human body. The success of a biomaterial relies on the host tissue's reaction with the foreign material.
A foreign-body giant cell is a collection of fused macrophages which are generated in response to the presence of a large foreign body. This is particularly evident with catheters , parasites , or biomaterials that are inserted into the body for replacement or regeneration of diseased or damaged tissues.
Many biomedical devices that come into contact with bodily fluids are susceptible to adverse foreign body response, or rejection and thus, failure of the device. The main mechanism of infection is the formation of a biofilm , which is a matrix of sessile bacteria consisting of around 15% bacterial cells by mass and 85% hydrophobic ...
That is, the polymer is unstable in a water based environment. This is the prevailing mechanism for the polymers degradation. This occurs in two stages. 1. Water penetrates the bulk of the device, attacking the chemical bonds in the amorphous phase and converting long polymer chains into shorter water-soluble fragments.