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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa.

  3. Rumack–Matthew nomogram - Wikipedia

    en.wikipedia.org/wiki/Rumack–Matthew_nomogram

    The original line, sometimes referred to as the Rumack–Matthew line, starts at 200 μg/mL at 4 hours and was published in 1975 by Barry H. Rumack and Henry Matthew. [5] When the NAC study began in 1976, the U.S. Food and Drug Administration (FDA) required a line that was 25% below the original.

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]

  5. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    These two hydrogen bonds serve an important role directing the drug into the S1 and S4 subsites of FXa. The first hydrogen bond is a strong interaction which comes from the carbonyl oxygen of the oxazolidinone core of rivaroxaban. The second hydrogen bond is a weaker interaction and comes from the amino group of the clorothiophene carboxamide ...

  6. Medicare now negotiating price of drug that costs $7,100 in ...

    www.aol.com/medicare-now-negotiating-price-drug...

    The annual list price of Bristol Myers Squibb’s Eliquis, a blood thinner that reduces the risk of stroke, is $7,100 in the US. ... compared with $14.6 billion and $9.5 billion on research and ...

  7. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruit–drug_interactions

    [19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...

  8. The Best Time of Day To Take Your Blood Pressure Meds To ...

    www.aol.com/best-time-day-blood-pressure...

    They shared their best practices for taking blood pressure medication, including timing and what to do if you miss a dose. Related: The 4 'Non-Negotiables' Everyone Should Adopt for Optimal Health ...

  9. Tylenol (brand) - Wikipedia

    en.wikipedia.org/wiki/Tylenol_(brand)

    Tylenol (/ ˈ t aɪ l ə n ɒ l /) is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol (known in the United States, Canada, and various other countries as acetaminophen ), an ...

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