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Microtia is a congenital deformity where the auricle (external ear) is underdeveloped. A completely undeveloped auricle is referred to as anotia. Because microtia and anotia have the same origin, it can be referred to as microtia-anotia. [1] Microtia can be unilateral (one side only) or bilateral (affecting both sides).
Branchio-oto-renal syndrome (BOR) [4] [5] is an autosomal dominant genetic disorder involving the kidneys, ears, and neck. It is also known as Melnick-Fraser syndrome. It is also known as Melnick-Fraser syndrome.
The isolated cause, a cause not associated with a syndrome, of anotia or microtia is not known, though it is believed to be of genetic basis. Developmentally, anotia/microtia occurs when certain tissues associated with the auricle do not develop. This rare defect may occur as part of a syndrome or as an isolated abnormality.
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[1] Freudenthal initially described these species in the genus Microtia in 1976 [ 1 ] (with reference to Microtus , a vole with similar teeth), but later the same scholar renamed the genus to Mikrotia in 2006, [ 2 ] since the name Microtia was already preoccupied by a butterfly genus named in 1864.
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