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Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.
B1 is typically only water soluble. Note that a substance can also be fat and water soluble, although there is no indication that benfotiamine is such a substance. --IO Device 18:42, 6 November 2011 (UTC) benfotiamine is a fat soluble form of thiamine. B1 is tradiitonally considered water soluble because most B1 is in the thiamine form.
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The results included sulbutiamine, fursultiamine (thiamine tetrahydrofurfuryl disulfide) and benfotiamine. These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduced to thiamine by cysteine or glutathione. [7]: 302 [8] It was first marketed in France by Servier in 1973 under the brand name Arcalion.
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Thiamine is one of the B vitamins and is also known as vitamin B 1. [1] [11] [12] It is a cation that is usually supplied as a chloride salt. [3]It is soluble in water, methanol and glycerol, but practically insoluble in less polar organic solvents.
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