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OPs are one of the most common causes of poisoning worldwide. [2] There are nearly 3 million poisonings per year resulting in two hundred thousand deaths. [2] [3] Around 15% of people who are poisoned die as a result. [2] Organophosphate poisoning has been reported at least since 1962. [7]
Health effects of pesticides may be acute or delayed in those who are exposed. [1] Acute effects can include pesticide poisoning, which may be a medical emergency. [2] Strong evidence exists for other, long-term negative health outcomes from pesticide exposure including birth defects, fetal death, [3] neurodevelopmental disorder, [4] cancer, and neurologic illness including Parkinson's disease ...
Cholinesterase-inhibiting pesticides, also known as organophosphates, carbamates, and anticholinesterases, are most commonly reported in occupationally related pesticide poisonings globally. [22] Besides acute symptoms including cholinergic crisis , certain organophosphates have long been known to cause a delayed-onset toxicity to nerve cells ...
Organophosphate pesticides were not commercialised until after WWII. Parathion was among the first marketed, followed by malathion and azinphosmethyl. Although organophosphates were used in considerable qualities they were originally less important than organochlorine insecticides such as DDT, dieldrin, and heptachlor.
As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of acetylcholine, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning. Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils).
The EPA and WHO both classify lindane as "moderately" acutely toxic. It has an oral LD 50 of 88 mg/kg in rats and a dermal LD 50 of 1000 mg/kg. Most of the adverse human health effects reported for lindane have been related to agricultural uses and chronic, occupational exposure of seed-treatment workers. [34]
The effects of poisoning vary drastically depending on dosage and levels of exposure. The types of pesticides most often present in poisonings are organophosphates and N-methyl carbamates, pyrethrin and synthetic pyrethroid insecticides, and organochloride insecticides. Certain fumigants, nematicides, herbicides, and dipyridyls are also common ...
Azinphos-methyl is a neurotoxin derived from nerve agents developed during World War II. [4] It was first registered in the US in 1959 as an insecticide and is also used as active ingredient in organophosphate (OP) pesticides. [6]