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Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. [ 6 ]
Her work led to the creation of the anti-retroviral drug AZT, which was the first drug widely used against AIDS. Her well known works also include the development of the first immunosuppressive drug , azathioprine , used to fight rejection in organ transplants , and the first successful antiviral drug, acyclovir (ACV), used in the treatment of ...
Excision enhancement mutations, typically M41L, D67N, K70R, L210W, T215Y/F, and K219E/Q, are selected for by thymidine analogs AZT and D4T; and are therefore called thymidine analog mutations (TAMs). [13] [14] [15] Other mutations including insertions and deletions in the background of the above mutations also confer resistance via enhanced ...
Margaret Fischl is an American physician, HIV/AIDS researcher, and professor of medicine at the University of Miami. [1] [2] She is notable for being one of the first researchers to discover the effectiveness of the antiretroviral medication azidothymidine (AZT) in treating patents with HIV/AIDS, as well as for helping build the University of Miami's AIDS Clinical Research Unit, of which she ...
Lamivudine/nevirapine/zidovudine (3TC/NVP/AZT) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [2] It contains lamivudine, nevirapine ...
The Arizona National Scenic Trail (AZT) is a National Scenic Trail from Mexico to Utah that traverses the whole north–south length of the U.S. state of Arizona.The trail begins at the Coronado National Memorial near the US–Mexico border and moves north through parts of the Huachuca, Santa Rita, and Rincon Mountains.
The drug zidovudine (AZT), a nucleoside reverse-transcriptase inhibitor (NRTI), was not effective on its own. It was approved by the US FDA in 1987. [124] The FDA bypassed stages of its review for safety and effectiveness in order to distribute this drug earlier. [125]
After synthesizing AZT, Horwitz went on to create many successful treatments for cancer and other diseases. At the time of his most recent findings, Horwitz was working for the Michigan Cancer Foundation with a federal grant from the National Institutes of Health; he retired in 2005.