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Serotonin pathways are thought to modulate eating, both the amount as well as the motor processes associated with eating. The serotonergic projections into the hypothalamus are thought to be particularly relevant, and an increase in serotonergic signaling is thought to generally decrease food consumption (evidenced by fenfluramine , however ...
3356 15558 Ensembl ENSG00000102468 ENSMUSG00000034997 UniProt P28223 P35363 RefSeq (mRNA) NM_001165947 NM_000621 NM_001378924 NM_172812 RefSeq (protein) NP_000612 NP_001159419 NP_001365853 NP_766400 Location (UCSC) Chr 13: 46.83 – 46.9 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor ...
One notable example of functional selectivity occurs with the 5-HT 2A receptor, as well as the 5-HT 2C receptor. Serotonin, the main endogenous ligand of 5-HT receptors, is a functionally selective agonist at this receptor, activating phospholipase C (which leads to inositol triphosphate accumulation), but does not activate phospholipase A2, which would result in arachidonic acid signaling.
15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...
Serotonylation is the process by which serotonin effects the exocytosis of alpha-granules from platelets (also known as thrombocytes). [1] This involves the serotonylation of small GTPases such as Rab4 and RhoA. It has been suggested that "further understanding of the specific hormonal role of 5-HT in hemostasis and thrombosis is important to ...
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors , although in some cases the term sensor is used. [ 1 ]
The Journal of Receptors and Signal Transduction is a peer-reviewed scientific journal that publishes laboratory and clinical studies, reviews, and brief communications on biological receptors and associated signal transduction pathways for ligands involved in the regulation of central and peripheral tissues and cells.
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells. Akt/PKB signalling pathway