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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1]
Oral niacin or niacinamide is given as a treatment for this condition in doses ranging from 50 to 100 mg twice a day, with a good prognosis if identified and treated early. [17] Niacin synthesis is also deficient in carcinoid syndrome, because of metabolic diversion of its precursor tryptophan to form serotonin. [4]
Side effects are minimal. [6] [7] At high doses, liver problems may occur. [6] Normal amounts are safe for use during pregnancy. [8] Niacinamide is in the vitamin B family of medications, specifically the vitamin B 3 complex. [9] [10] It is an amide of nicotinic acid. [6] Foods that contain niacinamide include yeast, meat, milk, and green ...
Flushing of skin (associated with niacin (vitamin B3) overdose) Skin disturbances (e.g. dryness, itching, cracking of skin, rashes, increased sensitivity to sun) Changes of hair texture (e.g. thickening and/or clumping of hair) Appetite loss; Constipation (associated with iron or calcium overdose) Nausea and vomiting; Diarrhoea
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [6]
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Inositol nicotinate is generally safe when taken by mouth, but possible side effects include: Stomach upset; Intestinal gas; Nausea; Liver damage (similar to other niacin products) [1] It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin. [4]
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