Search results
Results from the WOW.Com Content Network
A virus-infected cell releases viral particles that can infect nearby cells. However, the infected cell can protect neighboring cells against a potential infection of the virus by releasing interferons. In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR).
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...
Upon infection, STING from infected cells can sense the presence of nucleic acids from intracellular pathogens, and then induce interferon β and more than 10 forms of interferon α production. Type I interferon produced by infected cells can find and bind to Interferon-alpha/beta receptor of nearby cells to protect cells from local infection.
When released, they signal to infected cells and other nearby cells that a pathogen is present. [9] This signal is passed from one cell to another by binding of the interferon to a cell surface receptor on a naïve cell. [10] The receptor and interferon are taken inside the cell while bound to initiate expression of ISGs. [10]
Human interferon alpha-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. The first description of IFNs as a cellular agent interfering with viral replication was made by Alick Isaacs and Jean Lindenmann in 1957.
A special hormone called interferon is produced by the body when viruses are present, and this stops the viruses from reproducing by killing the infected cells and their close neighbours. Inside cells, there are enzymes that destroy the RNA of viruses. This is called RNA interference. Some blood cells engulf and destroy other virus-infected ...
Interferon-alpha, an interferon type I, was identified in 1957 as a protein that interfered with viral replication. [5] The activity of interferon-gamma (the sole member of the interferon type II class) was described in 1965; this was the first identified lymphocyte-derived mediator. [6]
n/a Ensembl ENSG00000197919 n/a UniProt P01562 n/a RefSeq (mRNA) NM_024013 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.44 – 21.44 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma ; MIM 147570) is produced ...