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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside . [1] [2] The term can also refer more generally to any organic molecule that contains amino sugar substructures.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Scarpetta, also known as Kay Scarpetta, [2] is an upcoming American television series created by Liz Sarnoff for Amazon Prime Video. It is based on the book series of the same name by Patricia Cornwell , and is produced by Nicole Kidman and Jamie Lee Curtis , who star.
2 seasons, 16 episodes: Season 3 due to premiere on March 13, 2025 [3] [4] Reacher: Crime drama: February 4, 2022 2 seasons, 16 episodes: Season 3 due to premiere on February 20, 2025 [5] [6] Renewed for season 4 [7] The Summer I Turned Pretty: Young adult romantic drama: June 17, 2022 2 seasons, 15 episodes: Season 3 due to premiere in mid ...
Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys.Because necrosis is often not present, the term acute tubular injury (ATI) is preferred by pathologists over the older name acute tubular necrosis (ATN). [1]
The nephro- and ototoxicity are thought to be due to aminoglycosides' tendency to accumulate in the kidneys and inner ear. [8] Diagram of the inner ear. Amikacin causes damage to the cochlea and vestibules. Amikacin can cause neurotoxicity if used at a higher dose or for longer than recommended.
ZeroZeroZero is an Italian crime drama television series created by Stefano Sollima, Leonardo Fasoli and Mauricio Katz for Sky Atlantic, Canal+ and Amazon Prime Video.It is based on the non-fiction book of the same name by Roberto Saviano, [1] [2] a study of the business around the drug cocaine, covering its movement across continents.
Combined with an aminoglycoside, it can increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blockage, result in some hearing loss or can continue to deafness. It could be a temporary symptom, but often be permanent. Neuromuscular blockade can lead to skeletal muscle weakness and respiratory depression or paralysis (apnea).