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Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside . [1] [2] The term can also refer more generally to any organic molecule that contains amino sugar substructures.
The nephro- and ototoxicity are thought to be due to aminoglycosides' tendency to accumulate in the kidneys and inner ear. [8] Diagram of the inner ear. Amikacin causes damage to the cochlea and vestibules. Amikacin can cause neurotoxicity if used at a higher dose or for longer than recommended.
Beginning in 2011, streaming service Hulu began to produce its own original content. The first production released was the web series The Morning After, a light-hearted pop-culture news show. [1] In 2012, Hulu announced that it would begin airing its first original scripted program, titled Battleground. [2]
Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys.Because necrosis is often not present, the term acute tubular injury (ATI) is preferred by pathologists over the older name acute tubular necrosis (ATN). [1]
Dopesick focuses on "the epicenter of America's struggle with opioid addiction" across the U.S. on how individuals and families are affected by it, on the alleged conflicts of interest involving Purdue Pharma and various government agencies such as the Food and Drug Administration and the United States Department of Justice, and finally, on the legal case against Purdue Pharma and their ...
On February 11, 2019, it was announced during the Television Critics Association's annual winter press tour that Hulu had given the production a series order. [4] The series premiered on December 6, 2019. [1] On June 10, 2020, Hulu canceled the series after one season. [2]
Painkiller is an American drama television miniseries created by Micah Fitzerman-Blue and Noah Harpster. [4] Based on Patrick Radden Keefe's New Yorker article "The Family That Built an Empire of Pain" and Pain Killer: An Empire of Deceit and the Origin of America's Opioid Epidemic by Barry Meier, [5] the series focuses on the birth of the opioid crisis, with an emphasis on Purdue Pharma, the ...