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Epoetin alfa, sold under the brand name Epogen among others, is a human erythropoietin produced in cell culture using recombinant DNA technology. [ 8 ] [ 9 ] Epoetin alfa is an erythropoiesis-stimulating agent. [ 8 ]
epoetin beta: NeoRecormon, made by Hoffmann–La Roche; Recormon; Methoxy polyethylene glycol-epoetin beta (Mircera) by Roche [20] epoetin delta: Dynepo trademark name for an erythropoiesis stimulating protein, by Shire plc [21] epoetin omega: Epomax; epoetin zeta (biosimilar forms for epoetin alpha): Silapo (STADA Arzneimittel AG) [22]
ESAs are administered via subcutaneous injections, often in doctor's offices for patients who lack the skill or dexterity to inject themselves, so the once- or twice-monthly dosing regimen for CERAs promises fewer costly, inconvenient office visits for patients requiring constant hemoglobin level maintenance for chronic kidney disease.
Erythropoietin (/ ɪ ˌ r ɪ θ r oʊ ˈ p ɔɪ. ɪ t ɪ n,-r ə-,-p ɔɪ ˈ ɛ t ɪ n,-ˈ iː t ɪ n /; [1] [2] [3] EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow.
Epoetin alfa; Epoetin beta; M. Methoxy polyethylene glycol-epoetin beta This page was last edited on 5 May 2019, at 10:21 (UTC). Text is ...
The erythropoietin analogs currently used to treat anemia in the United States are epoetin alfa (sold under the names Procrit and Epogen) and darbepoetin alfa (which is a more glycosylated form of epoetin, sold under the name Aranesp).
13857 Ensembl ENSG00000187266 ENSMUSG00000006235 UniProt P19235 P14753 RefSeq (mRNA) NM_000121 NM_010149 RefSeq (protein) NP_000112 NP_034279 Location (UCSC) Chr 19: 11.38 – 11.38 Mb Chr 9: 21.87 – 21.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52 kDa peptide with a single ...
Methoxy polyethylene glycol-epoetin beta, sold under the brand name Mircera, is a long-acting erythropoietin receptor activator (CERA) used for the treatment of anaemia associated with chronic kidney disease. [4] It is the first approved, chemically modified erythropoiesis-stimulating agent (ESA). [citation needed]