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  2. Ball and chain inactivation - Wikipedia

    en.wikipedia.org/wiki/Ball_and_chain_inactivation

    The ball enters the open channel and binds to the hydrophobic inner vestibule within the channel. This blockage causes inactivation of the channel by stopping the flow of ions. [1] [2] This phenomenon has mainly been studied in potassium channels and sodium channels. [3]

  3. Channel modulator - Wikipedia

    en.wikipedia.org/wiki/Channel_modulator

    Ion channels are typically categorised by gating mechanism and by the ion they conduct. Note that an ion channel may overlap between different categories. Some channels conduct multiple ion currents and some are gated by multiple mechanisms. Examples of targets for modulators include: Voltage-gated ion channels

  4. Nav1.4 - Wikipedia

    en.wikipedia.org/wiki/Nav1.4

    In hypokalemic periodic paralysis, arginine residues making up the voltage sensor of Na v 1.4 are mutated. The voltage sensor comprises the S4 alpha helix of each of the four transmembrane domains (I-IV) of the protein, and contains basic residues that only allow entry of the positive sodium ions at appropriate membrane voltages by blocking or opening the channel pore.

  5. Membrane transport protein - Wikipedia

    en.wikipedia.org/wiki/Membrane_transport_protein

    Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell. Active transport is the movement of a substance across a membrane against its concentration gradient. This ...

  6. Ion channel - Wikipedia

    en.wikipedia.org/wiki/Ion_channel

    [18] [19] [20] Many of the leak potassium channels are gated by lipids including the inward-rectifier potassium channels and two pore domain potassium channels TREK-1 and TRAAK. KCNQ potassium channel family are gated by PIP 2. [21] The voltage activated potassium channel (Kv) is regulated by PA.

  7. Piglet Learning to Hop Onto the Couch Will Only Work for Cheese

    www.aol.com/piglet-learning-hop-onto-couch...

    You've likely heard the saying, 'good things come in small packages,' and you'll find that it's especially true when it comes to pets. Our four-legged friends can leave paw prints on our hearts ...

  8. Voltage-gated ion channel - Wikipedia

    en.wikipedia.org/wiki/Voltage-gated_ion_channel

    Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na +), potassium (K +), calcium (Ca 2+), and chloride (Cl −) ions have been identified. [1] The opening and closing of the channels are triggered by changing ion concentration, and hence charge gradient, between the sides of the cell membrane.

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