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The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts.
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
18091 Ensembl ENSG00000183072 ENSMUSG00000015579 UniProt P52952 P42582 RefSeq (mRNA) NM_004387 NM_001166175 NM_001166176 NM_008700 RefSeq (protein) NP_001159647 NP_001159648 NP_004378 NP_032726 Location (UCSC) Chr 5: 173.23 – 173.24 Mb Chr 17: 27.06 – 27.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2 ...
Justin Bieber, Darren Criss, John Legend and Tyler Blackburn are among the male stars who have donned their birthday suits in nude social media pictures.
Image credits: Gilbert Flores/Variety/Getty Images Celebrity use and social media promotion of Ozempic have reportedly contributed to a shortage of the drug, which is intended to treat diabetes.
In March of that year, they posted a video describing themselves as "Costco Guys", which, by July, had received over 47 million views. [6] They subsequently began making videos of themselves rating products therein, either positively as a "boom" or negatively as a "doom".
In fact, a study in The Journal of Sexual Medicine found that nipple stimulation is arousing for 52% of men—yet only 17% of men have had their nipples played with during sex. Clearly, there’s ...