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The general structure of the endoplasmic reticulum is a network of membranes called cisternae. These sac-like structures are held together by the cytoskeleton . The phospholipid membrane encloses the cisternal space (or lumen), which is continuous with the perinuclear space but separate from the cytosol .
Secretory pathway diagram, including nucleus, endoplasmic reticulum and golgi apparatus. Nuclear membrane; Nuclear pore; Rough endoplasmic reticulum (rER) Smooth endoplasmic reticulum (sER) Ribosome attached to rER; Macromolecules; Transport vesicles; Golgi apparatus; Cis face of Golgi apparatus; Trans face of Golgi apparatus; Cisternae of ...
Two theories exist [9] — Vesicle fusion — where vesicles of nuclear membrane fuse together to rebuild the nuclear membrane; Re-shaping of the endoplasmic reticulum—where the parts of the endoplasmic reticulum containing the absorbed nuclear membrane envelop the nuclear space, reforming a closed membrane.
translation and folding of new proteins (rough endoplasmic reticulum), expression of lipids (smooth endoplasmic reticulum) single-membrane compartment: all eukaryotes: rough endoplasmic reticulum is covered with ribosomes (which are bound to the ribosome membrane), has folds that are flat sacs; smooth endoplasmic reticulum has folds that are ...
Association and maturation of rRNA and r-proteins result in the formation of the 40S (small) and 60S (large) subunits of the complete ribosome. These are exported through the nuclear pore complexes to the cytoplasm, where they remain free or become associated with the endoplasmic reticulum, forming the rough endoplasmic reticulum (RER). [20] [21]
The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. [3] The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. [ 4 ]
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Atlastins (ATLs) are a class of endoplasmic reticulum (ER) GTPases. Invertebrates have a single ATL, while vertebrates possess three ATL proteins (ATL1-3) that are differentially expressed. [1] ATL1 is the predominant paralog of the central nervous system, whereas ATL2 and ATL3 are mainly expressed in tissues outside of the CNS. [1]