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Necrotizing pneumonia (NP), also known as cavitary pneumonia or cavitatory necrosis, is a rare but severe complication of lung parenchymal infection. [ 1 ] [ 2 ] [ 3 ] In necrotizing pneumonia, there is a substantial liquefaction following death of the lung tissue, which may lead to gangrene formation in the lung.
These granulomas are the main reason for the name granulomatosis with polyangiitis, although it is not an essential feature. Nevertheless, necrotizing granulomas are a hallmark of this disease. However, many biopsies can be nonspecific and 50% provide too little information for the diagnosis of GPA. [12]
Focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, necrotizing glomerulonephritis: Granulomatosis with polyangiitis: Hakim Triad [1] (Adams Triad) Urinary incontinence, Gait disturbance, Dementia: Normal pressure hydrocephalus: Triad (Triad of Sandblom) Malena, Obstructive jaundice, Biliary colic: Hemobilia ...
"Pulmonary hyalinizing granuloma" is a lesion characterized by keloid-like fibrosis in the lung and is not granulomatous. Similarly, radiologists often use the term granuloma when they see a calcified nodule on X-ray or CT scan of the chest. They make this assumption since granulomas usually contain calcium, although the cells that form a ...
The commonest abnormality on lung function testing is a decrease in gas transfer. [2] Both obstructive and restrictive patterns on spirometry have been reported. [2] The differential diagnosis includes infection, other interstitial lung diseases and malignant disease including lymphoma.
Diagnosis of a lung cavity is made with a chest X-ray or CT scan of the chest, [2] which helps to exclude mimics like lung cysts, emphysema, bullae, and cystic bronchiectasis. [5] Once an imaging diagnosis has been made, a person’s symptoms can be used to further narrow the differential diagnosis .
Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds, a form of beryllium poisoning. It is distinct from acute beryllium poisoning , which became rare following occupational exposure limits established around 1950. [ 1 ]
Eosinophilic granulomatosis with polyangiitis consists of three stages, but not all patients develop all three stages or progress from one stage to the next in the same order; [7] whereas some patients may develop severe or life-threatening complications such as gastrointestinal involvement and heart disease, some patients are only mildly affected, e.g. with skin lesions and nasal polyps. [8]