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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Other severe side effects include unusual or severe tiredness or weakness, as well as yellowing of the skin or the eyes. [41] When baclofen is administered intrathecally, it may cause CNS depression accompanied with cardiovascular collapse and respiratory failure. Tizanidine may lower blood pressure. This effect can be controlled by ...
The effect is to prevent spasms of the stomach, intestine or urinary bladder. Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. [ medical citation needed ] Both of these drugs have side effects common to anticholinergics and can worsen gastroesophageal reflux disease (GERD).
Anticholinergics generally have antisialagogue effects (decreasing saliva production), and most produce some level of sedation, both being advantageous in surgical procedures. [8] [9] Until the beginning of the 20th century, anticholinergic drugs were widely used to treat psychiatric disorders. [10]
The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [9] [10] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [11]
College football fans on social media took issue with ESPN's focus on Jones, as the Fighting Irish were largely dominant in the 23-10 victory. The Notre Dame defense recovered two Georgia fumbles ...
Featuring Lisa Kudrow and Ray Romano, Netflix's new dark comedy "No Good Deed" is "about the highs and lows of searching for a safe, happy home."
Saclofen is a competitive antagonist for the GABA B receptor. [1] This drug is an analogue of the GABA B agonist baclofen.The GABA B receptor is heptahelical receptor, expressed as an obligate heterodimer, which couples to the Gi/o class of heterotrimeric G-proteins.
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