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Gout is a common form of inflammatory arthritis. It happens due to high levels of uric acid in the body. Researchers estimate that gout impacts one to four percent of people around the world.
Gout (/ ɡ aʊ t / GOWT [7]) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and swollen joint, [2] [8] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. [9] Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours. [5]
Colchicine is typically prescribed to mitigate or prevent the onset of gout, or its continuing symptoms and pain, using a low-dose prescription of 0.6 to 1.2 mg per day, or a high-dose amount of up to 4.8 mg in the first 6 hours of a gout episode. [13] [25] With an oral dose of 0.6 mg, peak blood levels occur within one to two hours. [50]
Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
How is gout treated and prevented? A doctor can diagnose gout by examining the joints and looking for a pattern of swelling. “We will also look for uric acid crystals either in your joints or ...
Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with p K a1 = 5.4 and p K a2 = 10.3. [ 7 ]
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