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Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. [2] It is also used for hemophagocytic lymphohistiocytosis. [3] It is used by mouth or injection into a ...
Etoposide, an epipodophyllotoxin. Epipodophyllotoxins are substances naturally occurring in the root of American Mayapple plant (Podophyllum peltatum). Some epipodophyllotoxin derivatives are currently used in the treatment of cancer. These include etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase II. [1]
Extracts from Camptotheca (the "happy tree" or "cancer tree") were used to develop the chemotherapeutic drug Topotecan. Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans. [1] [2]
Etoposide is a highly schedule-dependent drug and is typically administered orally and recommended to take twice the dosage for effective treatment. [ 13 ] [ 68 ] However, with the selective dosage, etoposide treatment is dose limiting proposing toxic effects like myelosupression (leukopenia) and primarily hematologic.
Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. The agents in this list are often combined into chemotherapy agent for polychemotherapy (combination chemotherapy).
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Teniposide is a semisynthetic derivative of podophyllotoxin [2] from the rhizome of the wild mandrake (Podophyllum peltatum). More specifically, it is a glycoside of podophyllotoxin with a D-glucose derivative. It is chemically similar to the anti-cancer drug etoposide, being distinguished only by a thienyl rest where etoposide has a methyl. [4]
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