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[h] The authors conclude that if replication is defined by a subsequent study finding a sufficiently similar effect size to the original, replication success is not likely even if replications have very large sample sizes. Importantly, this occurs even if replications are direct or exact since heterogeneity nonetheless remains relatively high ...
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
P-Values: The p-value is a measure of the probability that the observed data would occur by chance if the null hypothesis were true. In replication studies p-values help us determine whether the findings can be consistently replicated. A low p-value in a replication study indicates that the results are not likely due to random chance. [6]
Tandem repeats can occur through different mechanisms. For example, slipped strand mispairing, (also known as replication slippage ), is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases.
As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence. The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
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The replication itself should be transparent to an external user. In a failure scenario, a failover of replicas should be hidden as much as possible with respect to quality of service. [4] Computer scientists further describe replication as being either: Active replication, which is performed by processing the same request at every replica
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