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Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [ 1 ] [ 9 ] [ 10 ] It is mainly used in the treatment of heartburn and peptic ulcers .
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
These drugs are among the most widely sold drugs in the world, and are generally considered effective. [3] When these medications are used long term, the lowest effective dose should be taken. [4] They may also be taken only when symptoms occur in those with frequent problems. [5] Proton-pump inhibitors are named using the suffix "-prazole".
He went to work for ICI Pharmaceuticals in 1958 and, while there, developed propranolol, a beta blocker used for the treatment of heart disease. [5] Black was also responsible for the development of cimetidine, an H2 receptor antagonist, a drug used to treat stomach ulcers.
This page was last edited on 9 December 2016, at 08:59 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Unlike cimetidine, the first H 2 antagonist, famotidine has a minimal effect on the cytochrome P450 enzyme system and does not appear to interact with as many drugs as other medications in its class. Some exceptions include antiretrovirals such as atazanavir, chemotherapeutics such as doxorubicin, and antifungal medications such as itraconazole.
Some Costco eggs sold under the Kirkland Signature brand are being recalled due to the risk of salmonella, according to a notice posted by the U.S. Food and Drug Administration.
Metiamide is a histamine H 2 receptor antagonist developed from another H 2 antagonist, burimamide. [1] It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine (Tagamet). [2]
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