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[3] [4] It is generally considered safe in pregnancy and low doses appear to be safe while the user is breastfeeding. [5] After prolonged use, prednisone must be stopped gradually. [3] Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active.
Then change to oral hydrocortisone or cortisone as a single morning dose, and gradually decrease by 2.5 mg each week. When the morning dose is less than replacement, the return of normal basal adrenal function may be documented by checking 0800 cortisol levels prior to the morning dose; stop drugs when 0800 cortisol is 10 μg/dl.
In a prospective study, the cumulative incidence of CIL with high-dose prednisone therapy was found to be 61% after 3 months, 65% after 6 months, 68% after 9 months, and 69% after 12 months. [1] One study found that even a very low dosage of prednisone of 5 mg/day was associated with symptoms of "Cushing's syndrome". [ 1 ]
Prebediolone acetate (21-acetoxypregnenolone) = 3β,21-dihydroxypregn-5-en-20-one 21-acetate In addition to the above, various progesterone derivative progestins such as chlormadinone acetate , cyproterone acetate , medrogestone , medroxyprogesterone acetate , megestrol acetate , and segesterone acetate possess weak glucocorticoid activity ...
The article notes that prednisone can cause increased sex drive, which appears to be the opposite of what I find in a google search: prednisone reduces sex drive. I will edit accordingly. —The preceding unsigned comment was added by Ppe42 (talk • contribs) 02:05, 30 March 2007 (UTC). Both can occur, it depends when one makes the observation.
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recommended replacement for "μg" which may be confused with "mg" mdi metered dose inhaler m.d.u. more dicto utendus: to be used as directed mEq milliequivalent mg milligram mg/dL milligrams per deciliter MgSO4 magnesium sulfate: may be confused with "MSO4", spell out "magnesium sulfate" midi at midday min. minimum [or] minim [or] minutum
Patients on high dose sulfasalazine require folic supplementation (1 mg/day) because it inhibits folate absorption. If oral Mesalazine is still not working, prednisone is often given, starting at 40–60 mg/day. Prednisone often takes effect within 10–14 days. The dose should then be tapered by about 5 mg/week until it can be stopped altogether.