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DNA origami object from viral DNA visualized by electron tomography. [1] The map is at the top and atomic model of the DNA colored below. (Deposited in EMDB EMD-2210) . DNA origami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale.
Among these devices are force-sensing nano-structures, [2] gigadalton-sized DNA assemblies, [3] dynamically switching devices, [4] molecular motors, [5] [6] and virus traps. [ 7 ] [ 8 ] In the long term, Dietz hopes to make a significant contribution to the creation of molecular machines and systems with practical benefits for everyday life.
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These include examples such as DNA machines, periodic two- and three-dimensional lattices, polyhedra, and DNA origami. [2] It can also be used to create sets of nucleic acid strands which are "orthogonal", or non-interacting with each other, so as to minimize or eliminate spurious interactions.
In contrast, the SNA structure can be synthesized independent of nucleic acid sequence and hybridization, instead their synthesis relies upon chemical bond formation between nanoparticles and DNA ligands. Furthermore, DNA origami uses DNA hybridization interactions to realize a final structure, whereas SNAs and other forms of three-dimensional ...
Rothemund's DNA origami contains a long strand which folding is assisted by several short strands. This method allowed forming much larger structures than formerly possible, and which are less technically demanding to design and synthesize. [7] DNA origami was the cover story of Nature on March 15, 2006. [13]
DNA origami structures can be designed with specific attachment sites for other nanoscale components, such as nanoparticles, fluorophores, or proteins. By measuring the distances between these components on the origami structures, researchers can perform precise distance measurements at the nanoscale through atomic force microscopy (AFM) and ...
RNA origami is a much newer process than DNA origami; DNA origami has been studied for approximately a decade now, while the study of RNA origami has only recently begun. In contrast to DNA origami, which involves chemically synthesizing the DNA strands and arranging the strands to form any shape desired with the aid of "staple strands", RNA ...