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Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. [1] It is also used as a medication and diagnostic agent .
The ACTH test (also called the cosyntropin, tetracosactide, or Synacthen test) is a medical test usually requested and interpreted by endocrinologists to assess the functioning of the adrenal glands' stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH; corticotropin) or another corticotropic agent such as tetracosactide (cosyntropin, tetracosactrin; Synacthen ...
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. [ 1 ] [ 2 ] : 316, 1165 [ 3 ] : 84, 271 The form that is purified from pig pituitary glands is known as corticotropin [ 1 ] [ 2 ] : 316 is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior ...
The ACTH receptor plays a role in glucose metabolism when expressed in white adipose cells. When bound to ACTH, a short-term insulin-resistance occurs, and it stimulates lipolysis via hormone sensitive lipase. [16] Demonstrated in mice, ACTH promotes lipolysis in response to increased energy demand, notably in times of stress.
An ACTH stimulation test involving administration of corticotropin-releasing hormone (CRH) or another agent can differentiate this condition from ectopic ACTH secretion. In a patient with Cushing's disease, the tumor cells will be stimulated to release corticotropin and elevated plasma corticotropin levels will be detected. [ 8 ]
ACTH Peptide: anterior pituitary: corticotrope: ACTH receptor → cAMP: synthesis of corticosteroids (glucocorticoids and androgens) in adrenocortical cells: 15 Angiotensinogen and Angiotensin. AGT Peptide: liver: angiotensin receptor → IP 3: vasoconstriction. release of aldosterone from adrenal cortex dipsogen. 16 Antidiuretic hormone (or ...
Post-traumatic ACTH deficiency is usually associated with other pituitary defects; however, persistent or transient post-traumatic Adrenocorticotropic hormone deficiency has been reported. Adrenocorticotropic hormone deficiency can also be part of an atypical Sheehan's syndrome , be linked to an empty sella , and appear after brain tumor ...
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