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ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]
9636 100038882 Ensembl ENSG00000187608 ENSMUSG00000035692 UniProt P05161 Q64339 RefSeq (mRNA) NM_005101 NM_015783 RefSeq (protein) NP_005092 NP_056598 Location (UCSC) Chr 1: 1 – 1.01 Mb Chr 4: 156.28 – 156.29 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is ...
Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.
15959 Ensembl ENSG00000119917 ENSMUSG00000074896 UniProt O14879 Q64345 RefSeq (mRNA) NM_001549 NM_001031683 NM_001289758 NM_001289759 NM_010501 RefSeq (protein) NP_001026853 NP_001276687 NP_001276688 NP_001540 NP_034631 Location (UCSC) Chr 10: 89.33 – 89.38 Mb Chr 19: 34.56 – 34.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-induced protein with tetratricopeptide ...
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.
STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of interferon stimulated genes (ISG). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor ...
Viperin is an interferon-stimulated gene whose expression inhibits many DNA and RNA viruses including CHIKV, HCMV, HCV, DENV, WNV, SINV, influenza, and HIV. [6] Initially identified as an IFN-γ induced antiviral protein in human cytomegalovirus (HCMV) infected macrophages, it was reported that viperin could be induced by HCMV glycoprotein B in fibroblasts, but inhibits HCMV viral infection ...