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Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [5] [6] Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. [7]
66214 Ensembl ENSG00000102760 ENSMUSG00000022018 UniProt Q9H4X1 Q9DBX1 RefSeq (mRNA) NM_014059 NM_025427 RefSeq (protein) NP_054778 NP_079703 Location (UCSC) Chr 13: 41.46 – 41.47 Mb Chr 14: 79.53 – 79.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a protein that in humans is ...
In eukaryotes, the cell cycle consists of four main stages: G 1, during which a cell is metabolically active and continuously grows; S phase, during which DNA replication takes place; G 2, during which cell growth continues and the cell synthesizes various proteins in preparation for division; and the M phase, during which the duplicated ...
The cell cycle is a series of complex, ordered, sequential events that control how a single cell divides into two cells, and involves several different phases. The phases include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. [ 1 ]
Due to its involvement in degradation of various cell cycle regulators, as well as several compounds of signaling pathways (e.g. Notch), Cdc4 is a highly sensible component of every organism in which it functions. The cdc4 gene is a haplo-insufficient tumor suppressor gene. Knock-out of this gene in mice leads to an embryonic lethal phenotype ...
Cloning of the cyc gene revealed that it encodes a novel basic helix–loop–helix – PAS domain (bHLH-PAS) protein related to mammalian basic helix-loop-helix ARNT-like protein 1 (BMAL1), and that it likely binds to Clock to activate transcription of circadian rhythm genes. [4] Cycle gene expression has been discovered in a variety of cell ...
12571 Ensembl ENSG00000105810 ENSMUSG00000040274 UniProt Q00534 Q64261 RefSeq (mRNA) NM_001145306 NM_001259 NM_009873 RefSeq (protein) NP_001138778 NP_001250 NP_034003 Location (UCSC) Chr 7: 92.6 – 92.84 Mb Chr 5: 3.39 – 3.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. It is regulated by cyclins ...
Steps of the cell cycle. The restriction point occurs between the G 1 and S phases of interphase.. The restriction point (R), also known as the Start or G 1 /S checkpoint, is a cell cycle checkpoint in the G 1 phase of the animal cell cycle at which the cell becomes "committed" to the cell cycle, and after which extracellular signals are no longer required to stimulate proliferation. [1]