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13.4 Over-the-counter. 14 Adjunctive treatments. ... This is a complete list of clinically approved prescription antidepressants throughout the world, ...
A 2012 review focused on antidepressants and sleep found that mirtazapine reduced the time it took to fall asleep and improved the quality of sleep in many people with sleep disorders caused by depression, but that it could also disturb sleep in many people, especially at higher doses, causing restless leg syndrome in 8 to 28% of people and in ...
[13] [46] [49] This is in apparent contrast to SSRIs and SNRIs, which appear to require a minimum of 70 to 80% occupancy for antidepressant efficacy. [13] [46] [50] These findings are suggestive that the antidepressant effects of vortioxetine may be mediated by serotonin receptor interactions in addition to serotonin reuptake inhibition.
Atomoxetine is sometimes used in the treatment of cognitive impairment and frontal lobe symptoms due to conditions like traumatic brain injury (TBI). [47] [48] It is used to treat ADHD-like symptoms such as sustained attentional problems, disinhibition, [49] lack of arousal, fatigue, and depression, including symptoms from cognitive disengagement syndrome. [47]
Antidepressants are recommended as an alternative or additional first step to self-help programs in the treatment of bulimia nervosa. [60] SSRIs (fluoxetine in particular) are preferred over other antidepressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials.
Amitriptyline is effective for depression, [23] but it is rarely used as a first-line antidepressant due to its higher toxicity in overdose and generally poorer tolerability. [24] It can be tried for depression as a second-line therapy, after the failure of other treatments. [ 13 ]
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