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Vosoritide works by binding to a receptor (target) called natriuretic peptide receptor type B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). [5] FGFR3 is a receptor that normally down-regulates cartilage and bone growth when activated by one of the proteins known as acidic and basic fibroblast growth factor.
Medical condition Osteochondritis dissecans A large flap lesion in the femur head typical of late stage Osteochondritis dissecans. In this case, the lesion was caused by avascular necrosis of the bone just under the cartilage. Pronunciation / ˌ ɒ s t i. oʊ k ɒ n ˈ d r aɪ t ɪ s ˈ d ɪ s ɪ k æ n z / Specialty Orthopedic surgery Osteochondritis dissecans (OCD or OD) is a joint disorder ...
Epiphyseal growth plate: This transverse layer lies between the epiphysis and diaphysis. It’s composed of highly active chondrocytes and responsible for longitudinal bone growth. Consequently, the bone elongates at this growth plate until closure occurs at skeletal maturity.
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length).
The growth of a tusk takes the entirety of an elephant’s life. Tusks have many uses, such as a weapon in combat and a tool for foraging for food (by stripping bark or digging up roots ...
It might seem counterintuitive to let a steak stand after cooking, but it will be fine for the short resting period, and will still be plenty warm by the time it hits the plate.
However, these transverse notches lack the typical cell columns found in normal growth plates, and do not contribute significantly to longitudinal bone growth. [12] Pseudo-epiphyses are found at the distal end of the first metacarpal bone in 80% of the normal population, and at the proximal end of the second metacarpal in 60%.
The iconic singer-songwriter has long been a silver screen presence – as an actor, a subject of documentaries, and the figure in biopics. But Bob Dylan's love of movies has been a recurring ...